The Effect of Marrubium vulgare L. on Hyperglycemia- Mediated Oxidative Damage in the Hepatic and Renal Tissues of Diabetic Rats

Objective: In the present study, we examined the antioxidant effect of Marrubium vulgare L. infusion (MVI) on renal and liver function in alloxan diabetic rats. Materiel and methods: Animals were divided into 4 groups: the control, treated rats with MVI (MVI), diabetic (Diab) and diabetic treated rats with MVI (Diab + MVI), for 30 days. Thereafter, blood samples were collected for the dosage of glucose, creatinine (Cr) and insulin level. The Kidney and liver were removed for the determination of oxidative stress markers [malondialdehyde (MDA), glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (Cat), reduced glutathione (GSH) and vitamins (E ant C)] and histopathology examination. Results: Diabetic rats exhibited hyperglycemia, elevated of plasma Cr and insulin, oxidative stress markers impairment and renal and hepatic histological alteration. The treatment with MVI attenuates blood glucose, Cr and insulin level; reduced oxidative stress damage and improves histopathological alterations. Conclusion: The hypoglycemic effect and hepatorenal damage improvement of M. vulgare extract may be in part due to its antioxidant properties.